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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S2
All Species:
45.15
Human Site:
Y176
Identified Species:
76.41
UniProt:
P20042
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20042
NP_003899.2
333
38388
Y176
G
S
E
R
D
Y
T
Y
E
E
L
L
N
R
V
Chimpanzee
Pan troglodytes
NP_001092026
333
38354
Y176
G
S
E
R
D
Y
T
Y
E
E
L
L
N
R
V
Rhesus Macaque
Macaca mulatta
XP_001105021
327
37615
Y170
G
S
E
R
D
Y
T
Y
E
E
L
L
N
R
V
Dog
Lupus familis
XP_534387
333
38269
Y176
G
S
E
R
D
Y
T
Y
E
E
L
L
N
R
V
Cat
Felis silvestris
Mouse
Mus musculus
Q99L45
331
38074
Y174
G
S
E
R
D
Y
T
Y
E
E
L
L
N
R
V
Rat
Rattus norvegicus
NP_955412
333
38225
Y176
G
S
E
R
D
Y
T
Y
E
E
L
L
N
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510012
334
38349
Y177
G
S
E
R
D
Y
T
Y
D
E
L
L
N
R
V
Chicken
Gallus gallus
NP_989928
334
38418
Y177
G
S
E
R
D
Y
T
Y
D
E
L
L
N
R
V
Frog
Xenopus laevis
NP_001090286
332
38131
Y175
G
S
E
R
D
Y
T
Y
D
E
L
L
N
R
V
Zebra Danio
Brachydanio rerio
NP_997840
327
37446
Y170
G
S
E
R
D
Y
T
Y
D
E
L
L
N
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P41375
312
35199
Y155
G
S
D
R
D
Y
T
Y
D
E
L
L
K
R
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21230
250
27561
F134
K
K
T
A
F
S
N
F
L
E
I
C
R
L
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q41969
268
30644
R140
N
P
E
L
A
G
D
R
R
R
T
V
M
R
P
Baker's Yeast
Sacchar. cerevisiae
P09064
285
31556
P147
N
I
L
R
T
N
N
P
E
L
A
G
D
R
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
98.1
N.A.
95.5
96.6
N.A.
96.7
94.3
87.6
77.7
N.A.
58.2
N.A.
45.3
N.A.
Protein Similarity:
100
99.6
98.1
99.4
N.A.
98.1
98.5
N.A.
98.1
96.7
92.1
87.3
N.A.
69.9
N.A.
56.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
80
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.2
39.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
54.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
8
0
79
0
8
0
36
0
0
0
8
0
0
% D
% Glu:
0
0
79
0
0
0
0
0
50
86
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
79
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
8
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% K
% Leu:
0
0
8
8
0
0
0
0
8
8
79
79
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% M
% Asn:
15
0
0
0
0
8
15
0
0
0
0
0
72
0
0
% N
% Pro:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
86
0
0
0
8
8
8
0
0
8
93
0
% R
% Ser:
0
79
0
0
0
8
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
8
0
8
0
79
0
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
79
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
79
0
79
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _